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زیست شناسی::
چندریختی تکنوکلئوتیدی
Single-nucleotide polymorphism (SNP) arrays
sequencing, pyrosequencing offers the advantage of short read length when analyzing genetic variants for applications such as SNP genotyping or detection of known
and single-nucleotide polymorphism (SNP) arrays.
with SNP arrays providing the additional ability to detect large regions of homozygosity in the genome.
Single-nucleotide polymorphism (SNP) arrays were originally designed to genotype
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عمومی::
پلی مورفیسم تک نوکلئوتید، پلیمورفیسم تکنوکلئوتیدی، پلی مورفیسم تک نوکلئوتیدی
The most commonly occurring form of genetic variability is the single nucleotide polymorphism (SNP, often called "snip"), resulting from a change in a single nucleotide base pair within the gene sequence (Ahles and Engelhardt, 2014).
Synonymous SNPs in the coding region of a gene generally result in no change in the amino acid sequence of the eventual protein product.
Non-synonymous SNPs in the coding region will result in a change in the amino acid sequence of the protein.
However, non-synonymous SNPs have the potential to drastically alter the function of protein (Ahles and Engelhardt, 2014).
Genetic variants that result from the insertion or deletion of a nucleotide in the coding region are also classified as SNPs.،2p24 by single nucleotide polymorphism (SNP) and copy number variant
nucleotide polymorphisms (SNP) to assess the number of alleles in a
Some commercial microarrays combine CGH and SNP detection
(ArrayCGH) compared with SNP array
(b) SNP arrays generate log ratio (black line) by comparing the signal intensities،Single nucleotide polymorphism testing
These tests evaluate large numbers of variations (single nucleotide polymorphisms or SNPs) across a person's entire genome.
For example, the pattern of SNPs might indicate that a person's ancestry is approximately 50 percent African, 25 percent European, 20 percent Asian, and 5 percent unknown.
In ethnic groups with a smaller range of genetic variation due to the group's size and history, most members share many SNPs, and it may be difficult to distinguish people who have a relatively recent common ancestor, such as fourth cousins, from the group as a whole.
The most common type of genetic variation is known as a single nucleotide polymorphism or SNP (pronounced "snip").
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